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彩票55集团:????

2019-05-22 13:45:29?: 捷豹彩票网站 ?
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30R????????R?α??100/?Ч????????Ч????R?20mg/d?20mg/d????Ч???

R????飬?????????P450 (CYP) 2C19 *2/*3?CYP2D6*4/*5??лй??R?ε????Щ?Щ??

?????????????ɡ????????о1700??μ5飬???????(?)?8????ú?(Hamilton DepressionRating Scale-17, HDRS-17)?3?????????HDRS-17?7??????Ч?????????μ???(?=1.71,95%[CI]1.17-2.48;P=.005)?????5о??????

????(ISPG)??Э????????ISPG??в????????????????????仯ISPG??????(CPIC)FDA??????嵥

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??????УCPIC??FDAá???????FDA?II豸???????FDA???汣????Ще??????Щ?????????????????п?е??????????????FDA 510(k)ɡ

????????FDA?Щ????豸??е?ж???????????и???FDA??顣???FDA???????Σ?ò??????ù??ò??Ч???FDA鹫??????????

FDA

FDA???????????????????Щ?ì?

FDA??20181031?FDA??23andMe??????33??????????????(CYP2C19CYP2C9CYP3A5UGT1A1DPYDTPMTSLC01B1CYP2D6)??л????????FDA?ù???ò?????33???FDA黹?????????23andMeδ?ò??屨棬?FDA????и??FDA???>18?????ò?????FDAκ??????????????????FDA?о?????????FDA????б?а23andMe??????

FDA??2018111?????????????????????δFDA飬????????2???????

ЩFDA??23andMe??????????????y??FDA??κ???????

FDA?

FDA???????Щ??Щ?????й????жFDA?????????????FDA?????????????????FDA????FDA???飬FDA?????ù??????

????(http://www.911.8664477.com/)????й????л?CPIC??FDA?????????????FDA?????????>120???а??

?R???2л????ЩCYP?л?л?????????±гFDA??????е???мR?????Щ????

FDA????????

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漰л??

FDA???

PharmGKB?

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CYP2B6 (major)

?CYP2B6????л?FDA???в?а?仯?

http://www. pharmgkb.org/pathway/PA166170276

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CYP2C19 (major) and CYP2D6 (minor)

CYP2C19л???????QT?,20mg/dCYP2C19л??CYP2D6???л?????CYP2D6?л???л???鲻?CYP2D6л???

http://www. pharmgkb.org/pathway/PA164713429

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CYP2D6 (major), CYP3A4 and CYP1A2 (minor)

??CYP2D6л???л??κμ

http://www. pharmgkb.org/pathway/PA166121347

FDA????йCYP2C19CYP2D6л???仯?

http://www. pharmgkb.org/pathway/PA166181117

CYP2D6

?л(CYP2D6лγ)л???CYP2D6л???????

http://www. pharmgkb.org/pathway/PA166014758

CYP??P450PharmGKB????

?RFDA?????и???????????R??SSRI???????????FDA?????лCYP2D6CYP2C19????????л?CYP2D6л?????R?

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Vicki L.Ellingrod,PharmD, FCCP. Pharmacogenomics testing: What the FDA says. Current Psychiatry, April 2019

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彩票55集团:?

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